Slay the Spire 2 Complete Relic Tier List (2026)
A single relic can win a run. In Slay the Spire 2, relics are more impactful than cards because theyre permanent. This tier list ranks every relic by win rate impact.
S Tier Run-Winning Relics
These relics are so strong they single-handedly win runs. If you see one take it, no questions asked.
Universal S-Tier
| Relic | Effect | Why S-Tier |
|---|---|---|
| Prismatic Shard | Choose character cards in rewards | Build hybrid decks. Game-breaking. |
| Runic Pyramid | Keep hand on rest | Removes hand RNG. One of the strongest relics. |
| Dead Branch | Exhaust card add random Skill | Infinite card generation. Breaks the game. |
Ironclad S-Tier
| Relic | Why S-Tier |
|---|---|
| Mark of Pain | Start with 2 Wounds. With Corruption = infinite 0-cost Skills. |
| Meat on the Bone | Revive once at 1 HP. Insurance policy. |
A Tier Build-Enabling Relics
- Poison Build: Twisted Funnel (+3 poison), Strange Spoon (25% negate attack)
- Block Build: Runic Capacitor (+5 Block each rest), Tiny House (heal 5 HP each rest)
- Strength Build: War Paint (+1 Strength start), Vajra (+1 Strength)
- Orb Build (Defect): Data Disk (start with random Orb), Symbiotic Virus (Orbs trigger +1)
B Tier Solid Pickups
- Bag of Marbles Enemies appear 1 at a time. Great for slow decks.
- Juzu Bracelet +2 max HP per elite killed. Stacks. 15 elites = +30 HP.
- Weapon Hilt +4 damage on next attack after rest. Simple, effective.
C Tier Trap Relics
- Mark of the Bloom Cant heal above 50% max HP. Single-handedly loses runs.
- Astrolabe Upgrade ALL cards in deck. Actually terrible (wastes upgrade slots on Strikes).
- Dried Rose Spawns minion (8 damage). Too little value for a relic slot.
The Dream Combo: Runic Pyramid + Dead Branch + Corruption = You literally cannot die. Your hand is always full of Skills.